Genomic Technologies

Using traditional whole genome short-read next generation sequencing (NGS) and bioinformatic tools (see Computational Genomics), we and others, have identified novel Structural Variation (SV) derived prostate cancer regulators and drivers, while reporting reduced sensitivity and precision with increased SV complexity. While partnering with Australian genomic facilities for the purposes of both short and long-read NGS interrogation, we have established a non-sequencing optical genome mapping (OGM) laboratory housing the Bionano Saphyr gen2 instrument with the aim to detect the close to complete complement of complex tumour derived variation, we term the ‘structome’.

Having been the first to establish OGM in Australia in 2014, with the support of the Faculty of Medicine and Health, we have now been able to expand on our expertise to facilitate projects both within our Faculty, the broader University and Australasian community.

For any requests, please contact Dr Mehedi Hasan at md.m.hasan@sydney.edu.au